Isaac Goodwin (c. November 10, 1695 - August 15, 1766) was a Grand Juror and Selectman of West Hartford, Connecticut, and the great-grandson of Ozias Goodwin, one of the founders of Hartford, Connecticut. He was baptized on November 10, 1695 as the son of Nathaniel Goodwin and Mehetable Porter in West Hartford. Around 1720, he married his first wife, Hannah Morgan (b. November 24, 1703), the daughter of Thomas and Rachel Morgan. Between 1721 and 1737, he and Hannah Morgan had eight children. After 1737, his first wife died, making him a widower. However, he soon married his second wife, Ruth Gaylord (b. October 18, 1704), the daughter of William and Hope Gaylord of Hartford. The couple had one child together in 1743.
Isaac Goodwin served as West Hartford's Grand Juror in 1741 and Selectman in 1742. On August 15, 1766, he died, leaving his widow Ruth and his children. She later died around May 1773.
By first wife, Mehetable (Porter) Goodwin:
- Sarah Goodwin - m. Elizur Wright
- Mehetable Goodwin - m. Lamrock Flower, Jr.
- Anna Goodwin - m. Ebenezer Mix
- Morgan Goodwin - m. Mary Hawley
- Deliverance Goodwn (d. circa 1760) - m. Zenas Brace
- Isaac Goodwin - m. (1) Mercy Merrill (2) Deborah Francis
- Uriah Goodwin - m. Mabel Francis
- Ebenezer Goodwin (bapt. Oct. 30, 1737) - died young.
By second wife, Ruth Gaylord:
- Ebenezer Goodwin - m. Ame Webster